Tricyclic Antidepressant (TCA) Overdose – Symptoms & Management Flashcard ( Medical Learner)

Tricyclic Antidepressant Overdose

Presentation

• Dilated pupils
• Dry mouth & skin
• Hypotension
• Urinary retention
• Tachycardia

Investigations

• ECG: Widened QRS & broad complex tachycardia
• ABG: Metabolic acidosis

Management

• IV Sodium bicarbonate (50 ml of 8.4%)
• IV fluids (Normal Saline)
• Continuous ECG monitoring

Key Concept

• TCA → Na⁺ channel blockade → QRS widening → Treat with bicarbonate

Quick Notes:
Anticholinergic + cardiotoxic overdose.
Wide QRS → Give sodium bicarbonate.
Risk of seizures & arrhythmias.

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